r/DrugNerds•
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Do any of the synthetic cannabinoids/CB-1/2 agonists lack the GABA antagonism of THC? (therefore rendering it potentially anxiety free?)

I recently read that THC and it's analogues inhibit GABA receptor activity in multiple brain areas, which I'm thinking might explain why me and others I know get super anxious when we smoke. Anyone know if any of the synthetic analogues lack this quality or for whatever reason have less of a propensity for anxiety? I feel like Weed-like effects minus the GABA antagonism would make for a super relaxed and awesome high.

Posted Dec 2, 2012, 8:24 PM UTC

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