Need storage & configuration advice for Dell R740xd with Proxmox

I'm new to Proxmox, but after playing with it for 3 months now, I love it. I'm about to pull the trigger on a Dell R740xd box and wanted to get some advice from the community on the specs and storage to ensure I make the right purchasing decisions.

My goal is to build an all in one VM host for NAS, NVR, HomeAssistant, Docker (Plex, Sonarr, Radarr, SABnzbd, Portainer, etc), Linux VM for Observium SNMP, and a couple Windows and Linux servers for my sandbox. I also might host a few Linux and Windows VMs for testing.

Possible storage configuration?

I plan on using (2) 1TB M.2 SSD in RAID1 on dedicated Dell BOSS card for Proxmox OS.

(4) 2TB M.2 SSD for VMs and HDD cache.

(6) Dell 16TB 7.2K 6Gbps SATA 3.5 HDD for storage.

I have zero experience using ZFS, but from what I've read, it's pretty cool, so my disk (SSD/HDD) and controller selections need to be optimized for this.

Here are the specs:

Dell R740xd in (12) 3.5" configuration:

CPU

(2) Intel Gold 6132 14C 2.6Ghz 19.25M DDR4-2666 140W

MEMORY

(4) Dell 16GB DDR4 ECC RDIMM 3200Mhz

PRIMARY CONTROLLER

Dell HBA330 12Gb/s Host Bus Controller Mini Mono

or

Dell PERC H750 Adapter Controller

3.5" HARD DRIVES

(6) Dell 16TB 7.2K 6Gbps SATA 3.5 HDD

ONBOARD NIC

Dell Intel X520 Dual Port 10Gb SFP & I350 Dual Port 1Gb RJ45 rNDC

BOOT OPTIMIZED STORAGE (BOSS)

Dell BOSS Controller Full Height Card with 2x1TB M.2 SSD (RAID 1)

(for Proxmox OS)

Does anybody see anything obviously wrong with this configuration based on my desire to use ZFS and what I plan to host on this box?