Did I break my game? Evil Karma and 2 followers, missing screenshots and unsaved settings

I can’t remember when I installed this but I have FO3 GOTY and tried playing again yesterday.

The game wouldn’t launch so I tried the solutions that came up as the top search results (changing the .ini file and running a .bat file) because the path has OneDrive in it

The games launches now but I noticed:

In game:

• I was able to hire Jericho as a follower when I got to Megaton but when I checked my karma, it was neutral. I killed Butch and didn’t save his mom in the vault but can’t remember doing any good deeds.
• I blew up Megaton and killed Roy Phillips and followers
• I proceeded following the “follow Dad” questline and when I got into the Citadel, I meet Star Paladin Cross and got the dialogue about wanting to join me. I accepted the offer but when I checked my Karma, it was evil and said Urban Invader. I have 7 Charisma and I am level 9 at this point
• I now have both Jericho and Star Paladin Cross as followers

Others:

• Whenever I launch the game, it keeps showing the “detecting your video hardware”
• I can’t find my screenshots but I keep seeing the text saying it was saved and in .bmp. I can’t find anything in the My Games folder
• I enabled subtitles for dialogue but settings keep changing back
• I have Steam but the screenshots aren’t there

I feel like I broke the game. How do I fix these? If I uninstall and reinstall, will that be better?