If i force anisotropic filtering x16 in a program, should i keep negative LoD Bias to 'allow' or 'clamp' for better quality?

Let's say I'm playing a DLSS 4 supported game, and i want to increase my gane quality even more should i keep that negative LoD bias setting to allow or clamp?

The control panel says keep neg lod bias to clamp if you're using anisotropic filtering and use allow if you want performance.

So, which should i choose if my purpose my get better quality than more performance? Or is there even a major change at all?