Why does everything I take make me worse?

Can anyone give me an explanation? Whatever I've taken since I got sick has always made me worse, sometimes the worsening was associated with what I was taking it for and most of the time I've just had a general worsening of all my symptoms. I've never heard of anyone experiencing this and I can't explain, does anyone understand anything about this? What sense could it have? Why do I have this worsening?