Switch indoor head off or keep it running?

I have two 12k indoor heads, hooked up to a 24k outdoor unit.

Is it worth it (electricity wise as well as wear and tear on the indoor/outdoor unit) to switch off one unit when we don't need it overnight?

Or is it best to just set both and forget it and never really turn it off? This is for heating currently if it matters, but will then switch to cooling in the summer.

Thanks!