What charities have changed your life?

I'm a big believer in charity and put a portion of my income to it every month. It's a moral obligation as a Henry to help where you can (if we were taxed less I'm sure we would still look after eachother via charity as we would be able to afford to donate more).

However, I always find it hard to find charities where I feel like the money makes a tangible difference and isn't just going on admin or items that don't actually make a difference (large charities spend a lot on offices and staffing, while a small neonatal charity I was suggested mainly just buys chocolate for nurses and doctors). I want the money I donate to have as big of an impact as possible.

What charities have you seen change people's lives?