How can I move my game and my mods into another drive without risking losing my mods and breaking my game?

I’ve have got MO2 and my modding tools (e.g. LOOT) installed onto my root C drive, however my Skyrim SE (or AE which I have) is installed on Program Files x86 and I recently read that it could cause issues.

While modding Skyrim last year, I was only told to put the modding stuff outside of program files, but didn’t remember being told the same for the actual game. Since I have a second Steam folder location on my SATA SSD, that’s where I was thinking of putting all of my Skyrim stuff there, however I am worried that something might break as previously I transferred my Batman Arkham City game (which I also modded) from my C drive to the second drive and I keep getting this Microsoft.NET Framework error about access to document denied which the document is located on my C drive. All the other non-modded games that I transferred to my second harddrive seem to work perfectly fine.

All I’m asking is how I can safely move my Skyrim game, mods and mod tools without worrying of losing all my data or things breaking