Syncthing Setup

I have a gaming rig using Fedora 42 KDE. I would like to set it up as my central server. The details of the setup are:

1. I will be using a mechanical drive (shucked from an external exclosure) as the location for my files.
2. Would like to keep it running 24/7 but was wondering if there was a way to keep the network and hdd drive running while the desktop is asleep.
3. If I have to disable sleep is it possible to keep it running in a low powered state once left running for a while?

Thank you