Think my biologic is failing

Medication questions

42M, diagnosed in 2021, on a humira bio similar since 2023+mtx.

Up until recently, was working decently taking the humira every ten days, mtx every 7. I was not taking Tylenol or anti-inflammatories regularly (maybe 1/week) and with a controlled diet to eliminate inflammation responses from certain foods, was doing amazing.

However, about six weeks ago things started sharply down hill. I'm now seeing a roaring return of my symptoms such as:

-lethargy; -pain; -inflammation in joints, and other connective tissues, cartilage, and

  • hyper mobility in some joints (knees).

Worsening symptoms did correspond with some family stress regarding our kids and their education, but it's been a good three weeks resolved.

Any thoughts on "when has your biologic failed" and anyone who eventually had to move on from Humira or biosimilars, thoughts? What worked for you?

I have a decent Rheum and gold plated insurance, thankfully.

Appreciate thoughts

Posted May 4, 2025, 4:38 PM UTC

62
Loading comments…