NAC the day of MDMA - report
I have been using NAC in between my rolls ever since I started a couple of years ago which has been really useful, but have seen anecdotal reports of NAC taken too close to a roll dulling the experience somewhat. Have also seen anecdotal reports of it having no dulling effect at all. I have never had a bad or underwhelming roll since starting.
I had been taking 1200mg of NAC daily for the past few weeks and my planned roll ended up getting pushed up the day of after I had already taken my NAC, I decided to go ahead with it anyways for science!
While I had the same physical, visual, perceptual experience of a typical roll, the wave of serotonin, wellbeing, and empathy that is typically present was there very minimally to not at all. I do suspect that the NAC almost completely prevented any significant serotonin dump. While I still had a good time, I would definitely recommend ceasing NAC use a week prior to have a fully enjoyable roll.
The one upside is that usually I get really bad comedowns the second day after rolling but feel perfectly fine today! So I do feel pretty confident about NAC’s protective properties when taken in such close proximity to these sorts of drugs.
Hope this is helpful to someone!
Posted May 4, 2025, 4:46 PM UTC