Synergy

Folks, what is your nomination for the best item/weapon synergetic combo? I'm talking about the first 25 waves or so. Not folks on wave 190 with 8,000 luck and 16,000 damage.

My vote would be Sifd's for the item, and blunderbuss for the weapon.

I'd like to hear yours, as I am not a cookie cutter scared sausage player, and always like to try something new.