Methylated folate vs synthetic folic acid post MTX

I had my MTX shot around 3 weeks ago and my hcg was already down to 6 after two weeks.

I'm taking 800 microgram folic acid daily to build up my folate levels again, but just listened to a podcast stating that around 60% of people don't get an effect from synthetic folic acid, but need to get it in its natural form (like it is in spinach, lentils, etc). Even worse, it says that if we can't metabolize the synthetic folic acid, it will add up in our cells and let our body believe we have had enough of it, so it blocks whatever nature folate we might get through our diet.

Therefore, the podcast suggests that we only take supplements that are methylated (=in their natural form).

Does anyone have any knowledge in this field and can back it up?

I'm considering to buy methylated supplements and skip the synthetic ones if they will get my levels back up quicker, but they're super expensive so I'm also hesitant if this isn't necessary.

Also thought other people in here might find this topic interesting.<3

Posted May 7, 2025, 2:41 PM UTC

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