Pre-PMF

Other (CML, MDS, etc)

So I had my follow up with heme today and he said my bone marrow biopsies were essentially normal but since I have DMNT3A mutation this is pointing towards a very early PMF. I do not yet meet the WHO criteria for PMF so it’s just a watch and wait game for now. He recommended a baby aspirin and labs in 3 months then 6 months and a f/u with him at 6 months. He said if my platelets are stable he will go to every 6 months for labs but if they trend up or down he will continue every 3.

It is my understanding that IF it eventually progresses to meet WHO criteria for PMF this particular mutation has a poor prognosis. Any further recommendations or thoughts appreciated. My previous post has all of my BMB results as well as chromosome analysis, iron studies, and NGS.

Posted May 7, 2025, 2:42 PM UTC

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