Spouse Visa UK apply from Spain

Hello, I need someone who know's if this is right please. Im Spanish living in UK with pre settle status and I want to apply for the spouse visa in UK for my wife, she is Chilean and we are married. She is in the process to take the TIE, can we apply from Spain if she only have the NIE? Or we have to wait for the TIE to apply from Spain? Is better if she apply from Chile? Thank you.