can anyone please ELI5 the difference between beta blockers and α2-adrenergic meds

Question & TLDR

• In the context of adhd stimulants (IR Dex)??
• what effects would a beta blocker have that differs from my Clonidine?
• does a beta blocker cause less sedation than Clonidine?

Extra random Context (you don’t have to read it)

I have had mild ME/CFS 2017, and IR Dex (low dose) for about 5 years now. The stims have helped my ADHD immensely, and I am in remission from my chronic MDD that was quite severe (yay). I appear to tolerate this stimulant dosing schedule without obvious PEM.

But, as you can imagine, the stim meds give me adverse side effects that my body never adjusted to. Notably, I am concerned about my high heart rate, high blood pressure and other ANS dysregulation you can probably guess.

While off adhd meds, I don’t have symptoms of any Dysautomnia conditions (outside of ME overlap symptoms). But my ME symptoms off meds are still present and awful.

I have tried

• reducing dose
• changing medications
• not taking stimulants
• any nervous system relaxing approaches you can think of etc.

I have been taking an α2A medication (Clonidine) once per night for sleep. This helps me fall asleep, but has no effect on my day time adverse symptoms, and it’s not supposed to either.

But when I have tried taking the Clonidine during the day time instead, to offset any adverse side effects from stims, it just makes me fall asleep/ sedated and it makes the adhd meds not ‘work’.

I am wondering if a beta blocker could help me better instead? my GP is worried that it will make me more fatigued and then have no benefit?