Does anyone else have chronic migraine syndrome plus Protein S deficiency or another coagulation disorder?

I've had chronic migraines my entire life and tested positive for Protein S deficiency two decades ago after my daughter had her first PEs. My daughter, my brother, my mother, my grandmother and many of my other relatives have Protein S deficiency so my diagnosis came as no surprise.

I had my first clot (DVT) last year and have been on Eliquis since. Everybody else in my family with Protein S deficiency is an Eliquis lifer so I'm resigned to being one, too.

Virtually all of them also suffer from migraines.

A few studies have been done that indicate a higher incidence of migraines in people with Protein S deficiency than those without. IMO there's definitely a link.

I'm curious if others have the same two disorders.

Posted Jul 24, 2025, 4:31 PM UTC

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