Multiple Doses per Day – More Intense Rebound? 🧨

I’m experimenting with ultra low dose naltrexone (ULDN) and wondering if anyone has tried taking it multiple times per day?

I have slow COMT and find the blocking phase very calming, but the rebound often feels overstimulating — like a surge of energy that’s too intense for my system.

I’m still adjusting my dose, but I can tell I need to go very low. Has anyone else noticed that dosing more than once a day makes the rebound more intense?

Also — how many times per day can you realistically dose ULDN without losing its effect or overloading your system?

Posted Aug 3, 2025, 2:53 PM UTC

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