stratocaster setup question, please help.

I just set up my stratocaster for 10-46 gauge strings last month, I wanted to try an 8-38 since I play alot of Pink Floyd. I'm already contented with how it plays, but I'm curious as I still haven't tried 8-38. Before I change my strings with an Ernie Ball Extra Slinky, I have a question.

Since there's a significant drop in string gauge, will I need to readjust the intonation and truss rod?