direct input buzzing??

I have been having the BIGGEST irritated headache when it comes to Direct Input. I run an M Audio 192 4 interface with FL Studio and I switch between the Nolly X, Gojira, and ToneSuite Distant guitar sim. There is a CONSTANT buzzing that is going on when I have the gates off in each of these sims, my actual gain on my audio interface is turned literally all the way down. I have new strings, Ernie Ball cable, and a decent Ibanez guitar. What is something I can do to help resolve this issue? I can link a video to what it sounds like as well. PLEASE HELP.