New here. Looking for some advice regarding Slow/Fast COMT and low B12 (should I take methylated or not)
Hello,
I learned several years ago I have the MTHFR mutation, I am “heterozygous for the C677T polymorphism in the MTHFR gene”. So I know I only have one mutated copy..
I’ve never had my vitamin levels checked before, so I recently did. I suffer severe OCD, and anxiety, and have physical symptoms too. My iron, ferritin, vitamin D are all optimal but my B12 is rather low (296). My doctor wants me to start a 1000 supplement every other day. My question is, do I get methylated or just regular?
And how do I know if I’m slow COMT or fast? I do have my raw data from 23andme.. is genetic genie reputable? I will note in my early 20s I tried to take SSRIs and had HORRIBLE reactions after a week trial (leads me to believe I am slow COMT and things don’t process quick enough through my system).
I’m just scared of supplement and medicine and don’t want to take anything that will amplify my anxiety!
TIA
Posted Aug 4, 2025, 4:25 PM UTC