Milk Thistle (Silymarin) Tylenol and Liver health

General Question

I did a search of community first and did not see an answer for my question.

I am trying to keep my liver from deteriorating. I have been taking milk thistle (silymarin) for years.

I'm currently taking Silymarin Complex from IHerb. While taking ten 325mg TYLENOL throughout the day. This is prescribed by my physician.

My question:

Should I take silymarin several hours apart from my medication that has 325 mg Tylenol in each tablet.

Or...can I take them at the same time?

I take 10 TYLENOL a day. Throughout the day...2 every 4-6 hours.

A pharmacist (several actually) wrote a letter to my doctor saying 12 a day will be the limit he will dispense because of the Tylenol content.

I have tried to find information on the internet about the interactions between silymarin and Tylenol.There isn't anything that tells WHEN to take it ,and HOW MUCH for the purpose to protect and detox my liver.

Could taking silymarin and Tylenol at the same time disrupt the pain medications ability to work to it's fullest extent?

I have been dx with a fatty liver. I know it's common. I do not drink any alcohol at all, and do not smoke any substances because of my fear for my liver's health.

The pharmacist did tell me several years back that I can't go on with this level of Tylenol daily.(I'm working on changing meds).

BTW, my PCP is not a fan of supplements and makes fun of me for taking them. So, suggesting consult your physician is not going to work for this question.

Posted Aug 11, 2025, 1:19 PM UTC

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