Degree vs Experience? Apply Anyway?

I'm currently in a VP role looking to go remote and most jobs seem to want a degree, some even say required. I never went to college. I started off working in manufacturing right out of high school and moved my way into the office, through several management rolesbat that company over 10 years, and now into my current role at a different company for the last 10 years basically doing account management, inside sales, marketing, and some e-commerce stuff. The company I work for is great but the pay is not competitive and I don't want to move my family.

Should I apply anyway? Can experience cancel out the need for a degree or should I seriously consider trying to get a degree at 38? I seem to do everything a lot of these companies are requiring I just lack the degree. Any tips are appreciated.