TIL there is a nonopioid medication for adults with moderate-to-severe acute pain, and I asked my doctor about it. Please see Important Safety Information and links to the full Prescribing Information, including Patient Information, at the end of this post.

IMPORTANT SAFETY INFORMATION

Do not take JOURNAVX^(®) if you take certain medicines that are strong inhibitors of an enzyme called CYP3A. Ask your healthcare provider if you are not sure.

Please see additional Important Safety Information below and Full Prescribing Information, including Patient Information, for JOURNAVX.

JOURANVX is a first-of-its-kind medication that works by reducing pain signals before they reach the brain. It’s a nonopioid prescription tablet to treat adults with moderate-to-severe acute pain.

How JOURNAVX Reduces Pain Signals Where They Start

JOURNAVX works in the peripheral nervous system—that’s the part of your nervous system that lies outside your brain and spinal cord; it sends information throughout your body to and from your brain
Along the peripheral nervous system, there is a specific channel called Na 1.8 that sends pain signals to the brain
JOURNAVX targets this specific channel, Na 1.8, reducing pain signals before they can reach the brain and are felt as pain
JOURNAVX works on Na 1.8, which is not expressed in the brain and is not related to addiction

Watch the video below to see how it works

https://reddit.com/link/1n7mt4x/video/q5dd1tq5tzmf1/player

Learn more

IMPORTANT SAFETY INFORMATION (CONTINUED)

Before taking JOURNAVX, tell your healthcare provider about all of your medical conditions, including if you:

● have liver problems. People with liver problems may have an increased risk of getting side effects from taking JOURNAVX

● are pregnant or plan to become pregnant. It is not known if JOURNAVX will harm your unborn baby. You and your healthcare provider should decide if you will take JOURNAVX while you are pregnant

● are breastfeeding or planning to breastfeed. It is not known if JOURNAVX passes into your breast milk. You and your healthcare provider should decide if you will take JOURNAVX while you are breastfeeding

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Taking JOURNAVX with certain other medicines may affect the way JOURNAVX and the other medicines work and may increase your risk of side effects. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.

Especially tell your healthcare provider if you take:

● hormonal birth control medicine (contraceptives) containing progestins other than levonorgestrel or norethindrone. If you take one of these contraceptives (progestins other than levonorgestrel or norethindrone), they may not work as well during treatment with JOURNAVX. You should also use nonhormonal contraceptives such as condoms or use other forms of hormonal birth control during treatment with JOURNAVX and for 28 days after you stop taking JOURNAVX

● medicines that are substrates of the CYP3A enzyme as they may become less effective during treatment with JOURNAVX. Your healthcare provider may need to adjust the dose of your medicine when starting or stopping JOURNAVX

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

What should I avoid while taking JOURNAVX?

Do not take food or drink containing grapefruit during treatment with JOURNAVX.

What are the possible side effects of JOURNAVX?

The most common side effects for patients treated with JOURNAVX included itching, muscle spasms, increased blood level of creatine phosphokinase, and rash.

JOURNAVX may temporarily reduce the chance of females becoming pregnant while on treatment. Talk to your healthcare provider if you have concerns about becoming pregnant. If you are using contraceptives, you should continue to use contraceptives during treatment with JOURNAVX.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all of the possible side effects of JOURNAVX.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

What is JOURNAVX?

JOURNAVX is a prescription medicine used to treat adults with moderate-to-severe short-term (acute) pain.

It is not known if JOURNAVX is safe and effective in children.

Please see full Prescribing Information, including Patient Information, for JOURNAVX.

JOURNAVX is manufactured for Vertex Pharmaceuticals Incorporated.

JOURNAVX and the JOURNAVX logo are registered trademarks of Vertex Pharmaceuticals Incorporated.

Posted Sep 3, 2025, 6:28 PM UTC · locked