do RPOs make oline blocking more difficult?

so we ran a boatload of RPOs , most resulting in lame WR screens. I have never liked the WR screen but that is bedsides the point. My question is whether the RPOs are a factor in the poor OL performance? I'm naively wondering if the OL needs to block for both eventualities and therefore is potentially less effective? The call is a rpo and we run vs the call in the huddle is a run? The call is an rpo and we pass vs the call in the huddle is a pass? Are those materially different tasks for the OL?