Better to take Ankinira/Kineret in the morning than before bed? (Recurrent)

If heart rate and stress is going to be higher during the day, does it make sense to have Ankinira at its most potent during those times? I read that the half life is only 6 hours. So taking it before bed is more convenient but I wonder if its less effective?

I'm still confused on the science though. Like maybe time of dose is irrelevant if heart rate just impacts healing time, and the original source of inflammation is independent of that?