Santa Rosa to Espana (near UST)

Hello! We have an errand this coming week sa malapit sa UST and we have a car na gagamitin. I am the only available driver. However, it is my first time driving sa Metro Manila. Any tips or anything I need to do before kami mag-travel? Tumingin na naman ako sa Google maps and it says mag skyway kami, doon ako medyo kabado.

Ang pinaka malayo ko na naman nakapag-drive is Batangas city.