People are just a product of their life
I'm sick of all the blaming and the shaming. I'm not trying to absolve anyone of anything, and I'm not saying that you couldn't do anything to improve your situation, but this rly all be predestined n shit, dawg.
Here's an example. A huge % of trans people have NCAH and don't know it. That leads to a low cortisol level which makes it really hard to have energy. Are you more "motivated" than this person you're shaming who's a NEET, or do they just have a disability they didn't know about?
Another example. A ton of transbians have mild estrogen resistance or aromatase deficiency or some other thing that messes with their estrogen signalling, because those mutations are correlated with the fetal hormone environment that makes an XY baby get born with a female gender identity but end up only into women. This is a real biological reason why transbians often pass less. This is not a reason to give up or doom. There are ways to help it. If you've got a mild estrogen resistance then you can counteract it with a higher estrogen dose. If you've got an aromatase deficiency that sucks for your pubertal masculinisation, but once you start taking exogenous hormones then it sorta goes out the window and isn't as relevant.
A ton of trans people have ADHD, and they have it for reasons that fuck with how their meds work. If you have an overactive COMT enzyme then your body methylates estrone really fast and it also does it to dopamine! Which means that your ADHD meds don't do as much and wear off quicker. Conversely, someone with slow COMT probably has way too much Estrone hanging around that clogs up the E receptors and stops Estradiol (which is stronger) from getting its turn. Dopamine is also not methylated as fast, meaning your ADHD meds last way too long and build up a tolerance really quickly.
My point with all of this is to fucking stop it with the comparisons.
Are you really better than that cringe hon? Or were you just born with genes and a hormonal environment that lead to you not getting dosed with the flavour of giga tism that makes them act that way? Do you really consider yourself "better" than people who literally never chose to be who they are? Most people never change themselves, and if they do, it's from an experience so traumatic that their brain's biology changed in a way that made it much easier for them to change as a person. Some people get so traumatised by an incident that they cortisol production fucks with their sex hormones and changes their personality. Did they just "have more motivation to change", or did they inadvertently introduce an extremely potent personality-changing chemical to the equation?
I know this is very "reddit atheist rick sanchez sheldon cooper" but our brains are just chemicals bro. You introduce a new chemical and shit changes. Motivation is actually a very small part of a human's capacity to change.
Okay, what do we do about this?
That depends.
If you're someone who has it good, but is super judgemental:
Read, n****, read! Read other people's experiences and empathise. Read studies on how this shit depends on certain genes. Go read old queer theory. Go look through the r/DrWillPowers wiki. You don't have to like Dr. Powers or agree with him, just look through the studies in the wiki and read them directly, ask Claude if you're not sure what something means.
If you're unhappy with your life
Introduce a chemical to change how your brain works. The one you need will depend on you. I'm sorry that I can't be more helpful than that. If you get your DNA tested you can use websites like geneticgenie to freely look through your data and spot things that might indicate you need to add X or Y nutrient to your routine. This shit can make a transformative difference.
My #1 recommendation is to stop being paranoid about "big pharma" or people "stealing" your dna data. That shit's stupid. Your life is fucked, yo! Who gives a shit if you get added to a Chinese database if you can fix your health and become a person that you like more? And yeah Big Pharma is evil but so is Big Oil, Big Food, Big Social Media, Big Tech.... the list goes on. I'm not handwaving the bad things they've done with a dismissive "there's no ethical consumption under capitalism" excuse, you just need to recognise that every industry is pushing you to consume more of their product out of a desire for profit, that's just how this shit works, yo!? Like car tires aren't evil just because Big Tire wants you to buy more of them, you shouldn't boycott food just bc Big Food has done immoral things??? there's nothing inherently evil about drugs as long as you're pretty sure they're more beneficial than not, which you can only do by either trying them or comparing them to your body's configuration (your genes, your signs& symptoms, etc) and coming to a conclusion about your personal situation.
Sorry for the ramble, but fuck you I don't have anyone to apologise for, you guys need to stop being like this. Oh and if you reply to this shit with an irony-poisoned nonsense I'm gonna piss in your cheerios and ransack your bookmarks folder. Yo mama checks into hotels and sleeps with the sheets tucked in.
Posted Oct 2, 2025, 1:42 PM UTC