r/IVF•
Wombat_99_

M-tese or repeat zymot and icsi (maybe add donor?)

Advice Needed!

Hi, I was hoping some of you who have been dealing with MFI could help me see my path forward here. I’m 38 F with endo and my husband is 52 M with severe MFI. During our first ER, I was growing 8 good sized follicles plus some smaller ones, but the doc was only able to reach 5 due to my endo. 3 mature, 3 fertilized, no blasts/all arrested on day 6. My RE thinks he could get 6-10 eggs from me next time by pushing on my abdomen (?), but the 0/3 blast rate is more than a bit concerning. My husband has had 3 SAs and all have been low quality. Motility ranging from 5 to 15 percent, low concentration, and dna frag from 36 to 24% (the latter being with short abstinence window). He already does all the supplements and has a very healthy lifestyle. We are looking to begin our next cycle and our options are the following:

  1. Repeat the short abstinence window w icsi and zymot and hope it works out better this time for some reason.
  2. See above, but split my eggs with his and donor sperm.
  3. M-tese for my husband.

We want to do everything we can to avoid a repeat of last time, but does m-tese seem likely to help? I am scared for him to have such an extreme procedure when our doc basically said we don’t know why the embryos arrested so this may be unnecessary. However if we dont do the m-tese now, our clinic wouldnt do it until March.

Has anyone had success with low motility/high dna frag and Zymot? Alternatively, has anyone tried the surgery for DNA frag reasons and can share their experience with me?

Posted Oct 10, 2025, 7:23 PM UTC

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