Ultra treatment resistant schizophrenia

What do you do when someone is ultra treatment resistant? We have officially lost hope. My brother has had schizophrenia for 16 years now. He has been on essentially every antipsychotic. Clozapine actually made him worse, and ECT had no effect. It seems like every option has been exhausted. We just don’t know what to do anymore. 😞 Every time he’s hospitalized the doctors just put him back on clozapine even though we tell them he was on it for 3 years at a therapeutic dosage and it made him significantly worse. And of course he never actually becomes stable at the hospital but is released because of insurance.