Genetic mutation and sex/gender

Maybe more of a biology question but...I think the situation that causes people to be trans can come from a number of causes and it is probably a case by case situation.

For one such cause, do you think it is possible that sometimes there was a genetic mutation and the person was originally the other sex and this early experience left a kind of impression on the soul? Such that the person always feels like the wrong gender? If so, is this a solidly Catholic case for transitioning?

and if so, how could the Church best support the discernment process?