Irritability on 2nd gen antihistamines, which is the best?
Hi All,
My allergist requires patients to pre-medicate with an antihistamine before immunotherapy.
The trouble is, antihistamines make me really irritable and cranky. I don't think it's a super common side effect (a lot of the descriptions of this are in kids), but boy is it miserable.
I've tried loratadine, cetirizine, and levocetirizine. All cause the crankies, but levocetirizine seems to be the least bad of the three. I haven't tried fexofenadine, but have heard it may be better.
Anyone else have experience with this? Any antihistamines that are better? Or other tips?
Posted Oct 28, 2025, 5:00 PM UTC
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