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This article describes a concise synthesis of lysergic acid from simple aromatic precursors. The successful strategy relies on the coupling, dearomatization, and cyclization of a halopyridine with a 4-haloindole derivative in 6 total synthetic steps from commercial starting materials.

par.nsf.gov/servlets/purl/10434702
par.nsf.gov

Posted Nov 1, 2025, 1:10 PM UTC

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