Tyenne - how long to start working?

Biologics/JAKis

Hi - started tyenne 4 weeks ago (5th shot this week). I was 100% controlled on enbrel for 16 years and failed after being switched to brenzys. Am in worst flare since being diagnosed in 2009. (Was diagnosed at 36)

For those of you on tyenne, when did it kick in for you? Am waiting to hear back from rheumy about a depo-medrol shot, but I’ve already had 2 this year while waiting for brenzys to work, so want to hold off if relief is around the corner.

Thanks in advance!

Posted Nov 5, 2025, 11:44 PM UTC

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