I’m overwhelmed at what to do next
I have the following:
- Heterozygous C677T (CT -/+)
- No issues with A1298C (AA -/-)
- Slow COMT Val158Met (AA +/+)
- I have had full genome testing done so there may be other stuff that’s important that I’m missing- I’m literally just learning about all of this over the past week so very new!
My background: Good health with perhaps more fatigue than others (but nothing awful) up until 2019 when I became very unwell with what I know now was/ is b12 deficiency. I have stayed pretty unwell the last 5 years with fatigue and classic b12 deficiency symptoms. I believe that this was caused by me developing SIBO that went untreated for all those years until now. My folate was also low as well as iron.
As of feb I’ve been treating my deficiency in this way: https://www.reddit.com/r/B12_Deficiency/s/gW5JuBcgWs.
Since this post I switched to a methylated b complex (from non methylated) after I realised about my MTHFR mutation. I feel a lot worse and a lot of b12 symptoms have come back.
On the b12 deficiency sub I was told I’m taking way too much folate- for reference I’m taking folic acid which never made me feel bad and I never got any side effects.
I don’t think I can continue taking the methyl b complex because I don’t think it’s helping. I did notice my mood is a lot better though??
I am so overwhelmed with what to do next! I just want to get better and not undo any of the progress I’ve made this year.
Posted Nov 10, 2025, 12:19 PM UTC