Tirzepatide anyone?

I tried ta-1 for immune recalibration but the dose was way too overstimulating. Now trying tirzepatide for MCAS and chronic inflammation… 1.0mg went well, tried to up my dose to a split dose of 1.0mg on Sundays and .25mg on Wednesday’s and I feel really off. I think it’s aggravated my mast cells (I have strong sensitivity and MCAS). Does anyone have experience with this? Or have any insight to offer?