Question about clomipramine and weight

NSFWSpoilerQuestion about OCD

Hi folks, hope this is ok to post here. Looking for second opinions/other folks experience with this medication or others, not medical advice!!!! And CW for discussion of weight/intentional weight loss.

32/f/USA

I’m currently on clomipramine for my OCD. It’s been a journey, but I find this medication helps a LOT with my intrusive/repeating thoughts. Truly life changing in a great way! However, I have been struggling quite a bit to lose weight. I went from 380lbs to below 300 with a lower carb diet and metformin. Then the GL-P1’s became popular and Ozempic only helped me lost like 10ish pounds and I was sick all the time, but Zepbound helped me get to 250, along with more exercise, etc. However, I’m on the highest dose, 15 mg (have been for a year) and metformin 750 mg 2x a day and I have stalled for about a year. I cannot for the life of me get the scale to move. I walk 10,000 steps most days of the week, do reformer Pilates 2-3 times a week, and go to the gym 1-2 times a week. I still follow a mostly low carb diet and I’ve worked with two RD’s who have said they don’t know why I’m not losing more.

Could the clomipramine be preventing my weight loss? My psych says it doesn’t cause significant weight gain, but I wonder if it’s just causing my stall. My inflammatory markers, my insulin (although I wish it was better), my WBC, so many things look so much better thanks to the weight loss/zepbound, but I’m so frustrated. I’ve never been this active in my life and yet not a single pound lost.

Any thoughts or recommendations would be great. Also open to hearing other possible treatments for OCD, especially as this one has killllllled my sex drive. I know weight gain and low libido are the two most common side effects with those kinds of drugs, but wanted to know if maybe there’s other options I haven’t heard of? TYIA

Posted Nov 14, 2025, 6:54 PM UTC

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