Gabapentin for Vocal Hoarseness
34M dealing with some ongoing vocal hoarseness and fatigue from a vocal injury 1.5 years ago. I originally hurt my voice singing, and had it diagnosed by an ENT 6 months later as unilateral vocal cord asymmetry / slow wave via stroboscopy. I then did speech therapy for 9 months (up to now) which has led to a gradual improvement both in symptoms and the chord asymmetry. Due to the injury / asymmetry there has also been vocal muscle tension contributing to overall voice pain and straining when talking, etc.
My question is, my ENT now wants to try 300mg gabapentin at night for 3 - 6 mo. And I'm wondering if any ENTs here can back this up as a recommended treatment or is it basically just anecdotal / a shot in the dark?
I have been trying to find literature on it and came across this paper from 2021 which mentions (pg 10) a study by Zaki et al where 85% of phonasthenia patients treated with gabapentin had a complete symptom resolution in 6 months. Zaki et al (2021) itself is a study from Egypt, who got the idea for treatment with gabapentin from Lee and Woo (2005) who treated patients with chronic cough with gabapentin due to sensory neuropathy of the laryngeal nerve - which Zaki et al. then applied to general hoarseness of variable etiology.
I'm guessing one study from Egypt is not exactly the gold standard of medical evidence. My ENT has also never mentioned concern for any laryngeal nerve involvement. So my concern is basically taking gabapentin for 3-6 months for no clear reason / possible side effects. Any input appreciated.
Posted Dec 1, 2025, 7:01 PM UTC