What's the most overlooked supplement?

I have high blood pressure, and I've done all of the lifestyle changes, tried beet extract, but to no avail, I ended up needing a starter dose of lisinopril. Not satisfied with this, I started looking for more ways I could lower my BP without increasing my meds.

Getting desperate looking for alternatives, I decided to use AI to analyze my DNA and give me suggestions. That's when it suggested Aged Garlic Extract (AGE). It probably suggested that cause I said I'm taking lisinopril so it added in BP lowering supplements.

Anyways, this isn't about that, I wanted to ask you all what are some of the most overlooked supplements with lots of research?

I'm surprised by my deep dive into AGE, it has so many benefits: lowering blood pressure, cholesterol and general cardiovascular health by reducing arterial stiffness and even cold recovery.

I want to share some of the research I've done, you can make your own interpretations.

Risk Factors, to get it out of the way first:

• Garlic/AGE is an anticoagulant, so it thins the blood. Don't take if you have surgery planned in 2 weeks, have open wounds, are pregnant or nursing, bleeding disorders, be aware of drug interactions
• Don't take if you're allergic
• Caution if your have a sensitive GI

Otherwise, generally highly tolerable.

Benefits

Ried, K., Travica, N., & Sali, A. (2018), Mean blood pressure was significantly reduced by 5.0±2.1 mmHg (P=0.016) systolic, and in responders by 11.5±1.9 mmHg systolic and 6.3±1.1 mmHg diastolic compared to placebo (P,0.001). N=88, time=12 weeks, 1.2g daily

Ried, K., Toben, C., & Fakler, P. (2013), meta-analysis of 39 trials demonstrates that garlic preparations reduce total serum cholesterol by 17±6 mg/dL and LDL cholesterol by 9±6 mg/dL in individuals with elevated levels (>200 mg/dL) when used for over 2 months, with an 8% cholesterol reduction associated with a 38% lower risk of coronary events at age 50.

Wlosinska, M., ... (2020), AGE inhibits coronary artery calcification (CAC) progression, lowers IL-6, glucose levels, and blood pressure in patients at increased risk of cardiovascular events in a European cohort.

Ockenga, J., et al. (2011), the group consuming the aged garlic extract appeared to have reduced severity as noted by a reduction in the number of symptoms reported (21% fewer, p < 0.001, z-test of proportions), a reduction in the number of days (61% fewer, p < 0.001, z-test) and incidences (58% fewer p < 0.001, z-test) 

And there are many more papers.... The meta-analyses are particularly interesting because they cite the underlying studies.

There are also possibly more benefits like antioxidant, anti-inflammatory, gut microbiome, but lowering BP is the most studied.

Caveats

Sound too good to be true? Well possibly, because a lot of these trials are small, N<100. But no one wants to pay for a large trial cause there's no money in it since garlic is not proprietary. So the science behind garlic as a treatment is not funded.

Not to get too tin foil hat crazy, but maybe big pharma would rather we all take proprietary manufactured meds than consider a natural remedy.

So how much should I take?

Most of the studies used 1.2g daily of AGE.

Fresh garlic isn't the same because the aging process stabilizes natural sulfur peptides into S‑allyl cysteine (SAC) and S‑1‑propenyl cysteine. (TBH my understanding is very shallow here so if anyone wants to chime in, that would be much appreciated).

What should I buy?

I don't want to promote a single product, but ConsumerLab's top pick for aged garlic is (Kyolic Aged Garlic Extract Extra Strength Reserve), and they approve (The Vitamin Shoppe Aged Garlic Extract).

Or maybe you can try aging it yourself? Would love to know how that goes.

There are also other form factors like black garlic, dried garlic, etc... I haven't been able to dig into those yet.

So....

Who else has their own favorite "most overlooked supplement" that's back by research? How do you go about this research? Cause this took me several hours.