Lost Alone and confused

So my wife of almost 15 years has given up on us. Caused my daughter to run away from home. And worst of all makes my daughter feel unloved. I by no means am the perfect husband. I hear but dont listen unless it is a serious problem. I work alot. I provide, dont cheat, and make sure everyone has a comfortable life. I carry alot of the relationship as she got diagnosed with thrombooytic pulmonary hypertension. 1 year after we were married. I stayed to help raise my stepson. I helped her through open lung surgeries to remove the blood clots in her lungs. I stayed though all the depression that came with that. She later broke her back by falling off a latter. I stayed to finish raising her son and our daughter. As I stated she recently ran away and yes she is home now. After showering her with the love I feel she needed. I am at a cross roads because my daughter knows I am unhappy. My wife lays around all day. Dosen't cook, clean or do dishes. She stays up all night sleeps all day. Doesn't help kid with school work blames my daughter for everything. I habe brought up these issues time and time again. She gets better then back to what it is. She blames me for not makimg enough money. And wants to live a social media life style. Shes close to 50 has to have oxygen on her at all times. She stated that she no longer wants sex just intimacy. I have no idea what that even means. My house is filthy. I try to keep up but she doesn't clean up after her self.

I know I need her to leave. For my kids sake. I am trying to rebuild this but maybe its lost.