Caffeine + Bupropion = No anxiety. Anyone else?

Question

I've been taking bupropion (150mg XL) for a few weeks now. For depression, not ADHD (which afaik I don't have).

I thought I had a honeymoon phase, but that was actually very short lived. I actually find if there's a delay between taking my dose and my first cup of coffee, that delay is ROUGH but my coffee perks me right back up. I think that was my honeymoon, actually. Not a honeymoon, but a period of time where my caffeine tolerance lowered, and now the honeymoon is fading as my morning coffee has less and less impact on me.

I also have anxiety, which I was told by the physician could be exacerbated. This hasn't happened for me. At all. In fact I'm less anxious than I've ever been in years. When I "come down" a bit in the afternoon and start to feel a bit "meh" again, I actually find it's the depression that persists, but the utter lack of anxiety is what keeps me afloat. And a second cup of coffee (or tea) has me bounce back.

This feels like the exact opposite of what everyone else experiences, and I'm not complaining, just wondering how much of an odd fuck I am. I tried searching for other similar experiences but all I've found is people lamenting they can't have coffee anymore since it causes anxiety and gives them the shakes lol

Posted Dec 5, 2025, 3:15 PM UTC

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