> First Runner-Up: Brundlefly (The Fly)

> Second Runner-Up: Miranda Priestly (The Devil Wears Prada)

> Third Runner-Up: Ragyō Kiryūin (Kill la Kill)

> Fourth Runner-Up: Ken (Bee Movie)

Current chart: Spider-Man - The Invisible Man, Captain America - Irene Engel (Wolfenstein), Wolverine - T1000 (Terminator), Hulk - Godzilla, Fantastic Four - The Master (Doctor Who), X-Men - The Borg (Star Trek), Daredevil - Gus Fring (Breaking Bad/Better Call Saul), Iron Man - Handsome Jack (Borderlands 2), Punisher - Anton Chigurh (No Country For Old Men), Ghost Rider - Pennywise (It)

Thor - Kratos (God of War), Dr Strange - Cthulhu (The Call of Cthulhu), Black Panther - Yautja (Predator), Captain Marvel - The Daleks (Doctor Who), Moon Knight - Freddy Krueger (A Nightmare on Elm Street), Black Widow - Albert Wesker (Resident Evil), Hawkeye - Cad Bane (Star Wars), Iron Fist -Shao Khan (Mortal Kombat), Luke Cage - Mr Glass (Unbreakable/Glass), Silver Surfer - Jobu Tupaki (Everything, Everywhere, All At Once)

She-Hulk - Saul Goodman (Breaking Bad/Better Call Saul), Deadpool - Road Runner (Looney Tunes), Namor - Andrew Ryan (Bioshock), Hank Pym - GLaDOS and Aperture Labs (Portal), The Wasp - Cruella de Vil (101 Dalmations)

Thank you for all your suggestions!

**For this prompt, manga and independent webcomics ARE allowed. The “non-comic book” part of the prompt was mainly for the Big 2 as well as Image, Dark Horse, Valiant, etc.**

Single highest upvoted comment wins

Cruella de Vil is the non-comic book archnemesis of The Wasp! Which FICTIONAL NON-COMIC BOOK villain would make a great archenemy to Blade? - Day 26