r/IUILadies•
Ginger36

18 months TTC, progesterone for 4 cycles, lots of breast/nipple growth but never a positive — anyone else?

Hi everyone, I’m hoping to see if anyone else has experienced something similar because I’m feeling really confused and discouraged.

My husband and I have been trying to conceive for 18 months now. I’ve had 2 IUIs (1 medicated cycle) and I’ve been on progesterone for the past 4 cycles. Every single month since we started TTC, I’ve had pregnancy-like symptoms to some degree, especially with my breasts and nipples. But since being on progesterone, the changes have been much more noticeable — my boobs feel fuller/plumper overall, my nipples have visibly grown, and this past week I’ve had nipple pain/sensitivity.

Today I’m 14 DPO and got a BFN this morning. I’m assuming I should stop the progesterone and wait for my period to start so we can try again. What’s really messing with my head is that after 18 months, I’ve never once had a positive test, yet I’ve had all this breast and nipple growth over time. It makes me wonder if it’s purely the hormones/progesterone, or if anyone else has experienced similar body changes without ever getting a BFP?

Has anyone else had significant breast/nipple changes on progesterone or during long-term TTC without ever seeing a positive? Did it end up meaning anything for you long-term, hormonally or fertility-wise?

I’m feeling pretty defeated and would really appreciate hearing others’ experiences. 🤍

Posted Dec 7, 2025, 4:49 AM UTC

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