Is this a sign of aggression?

My almost 2.5 months old shihtzu puppy growls and bites when we try to pick her up. She seems really angry and bites with a lot of force. Is this normal puppy behavior of sign of aggression? I do say No when she does that and sometimes when she bites I make a crying sound but she doesn't even flinch. Sometimes I put her down and go out of the room but that also doesn't seem to bother her. She just does her own thing. I wouldn't say she isn't affectionate since she greets us when we come home and wants to play with us.