Ultra cross pharmacodynamic resistance

Physician Responded

Hey! I’m posting here to see if anyone has something that will help with sleep and mental health issues. But it’s a VERY long shot. I’m in the 0.01% of population who has Ultra cross pharmacodynamic desensitization/resistance. I have had blood tests done to confirm it.

I can take morphine, opioids ,benzodiazepines, zolpidem, anti depressants, stimulants, whatever in the world that’s a drug and I get NO affect physically or mentally. And I have tried every medication possible.

It’s one of the most rare things but I’m hoping someone can help.

I suffer with PTSD, dissociation identity disorder, treatment resistance depression, anxiety and paranoia. Some nights insomnia

27 / female

Is anyone there with some advice or tricks😃

I have tried every talk therapy out there but it is ineffective.

Posted Dec 7, 2025, 12:46 PM UTC

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