new 'not proteomics' instrument purchase, looking for input
Hey,
Looking to buy an instrument to replace a QE+, which I have loved deeply. I run the 'not proteomics' section of a core facility so metabolomics, lipidomics, PFAS, environmental, synthesis confirmation, small molecule ID, samples from weird bacteria, basically everything.
I'm looking at
Thermo ID-X - in budget with the laser and extra resolution add ons. Interested because tribrid, very familiar with thermo and the laser will give some new capabilities. Not interested because it's 5 years old already and Thermo did not do well with software updates on the QE's (cannot do AcquireX etc despite the hardware being perfectly capable of doing so)
8600 - interested because I like qtof and I'm interested in what the EAD can do to help me resolve structures that CID cannot. Dubious about software given it seems to rely on MS-DIAL a lot. Haven't had a sciex instrument since the QStar (Elite?) and QTrap and not sure how the software and maintenance are these days
timsMetabo - interested because don't have any ion mobility capability at the moment, and have never had a bruker instrument so am curious to try. Not convinced that the ion mobility is practically really useful (or at least compared to higher res in the orbi or EAD in the 8600). Not sure about the software but at least it's inhouse and seems comprehensive.
Orbi Ascend is probably out of budget but if Thermo are kind then that's probably number one choice given it's a recent instrument and that's my main issue with the ID-X.
any thoughts? particularly pros and cons of things like software and maintenance or particular applications that shine or are not good
just writing the post was helpful to clarify things a bit!
Posted Dec 7, 2025, 10:57 PM UTC