Anyone have similar symptoms of itching with no obvious cause?

Support/Advice

I will summarize this as concisely as possible lol, but I am a 35 y/o female who has been dealing with unexplained vulvar itching for almost 2 years now. It all began after 3 confirmed UTIs (9/2023, 11/2023, 5/2025) and has not let up since. I have burning with urination off and on (usually more so if I try to pee before my bladder is completely full) and an itch on my inner labia and on the skin right at the opening of my vagina in the 6 o’clock area. My skin looks totally fine and shows zero signs of irritation and my discharge looks completely normal. I have seen countless urologists and gynecologists who aren’t sure what is going on, but I do have another follow up with a vulvar specialist next month. At my first appointment with her she didn’t seem to think it was definitely vulvodynia because I don’t really have any pain, just itching.

I am NEGATIVE for: UTIs, yeast, bv, trich, chlamydia, gonorrhea, hpv, mycoplasma genitalum, mycoplasma hominis, ureaplasma urealyticum, and ureaplasma parvum.

I have tried: topical estrogen cream, hydroxyzine, amitriptyline (still taking this), zyrtec (kinda helps), pelvic floor therapy, comfy cream (topical coconut oil based product made for the vulvar area).

Has anyone else experienced anything similar? What were your next steps or steps to figure out what was causing it?

Posted Dec 7, 2025, 11:46 PM UTC

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