Moondrop Blessing Dusk audio randomly dies permanently while playing League

I have a weird issue with my Moondrop Blessing Dusk IEMs, that I'm not sure if it's specific to my IEMs or to League, or to any other factors. Randomly when playing League/TFT, my audio in one or both IEMs will muffle out or die, until I restart my PC. This doesn't seem to happen in any other games I play. Notably, if it muffles instead of dying, it muffles higher frequencies severely more than lower frequencies.

I've tried the following:

• Different IEM cables

• Different 3.5mm ports on PC

• With and without DAC

• Different computers (only happens on my PC)

• Disabling all sound enhancements in Windows

I'm thinking of buying a new pair of different IEMs, but I'm not sure if there's anything else I should try first, or if a new pair would fix this problem. Any advice would be appreciated.