Is anyone running B2B + B2C under one store? What platform setup worked best?

We’re helping a brand that sells both to retail customers and wholesale clients. The workflows are completely different pricing rules, payment terms, permissions, order minimums, etc.

Trying to manage all of this under one Shopify storefront is… a lot.

Curious what setups you’ve found effective: Separate stores? Same store with customer tagging? Headless?

Would love any insight or real-life lessons.