Which rune is the best for armour?

So i recently gotten the arcane pixaxe trying to work on my armour and runes. I am trying to get 3 good luck runes on my pixaxe (might be better if there no people appearing out of nowhere or underground clearing the bombers) also getting life steal on my rapier. For armour what generally the best rune? also I think for the secondary buff I prob going with the increase hp